Our clinicians use medications only when clinically appropriate and supported by research. Options may include:

1. Bupropion (Wellbutrin®)

A norepinephrine-dopamine reuptake inhibitor (NDRI), bupropion is commonly used for depression and smoking cessation. Studies show it can:

Reduce stimulant cravings for some patients[1,2]

Support abstinence

Improve mood and energy

Reduce anhedonia

It is often most effective for individuals with co-occurring depression.

2. Mirtazapine (Remeron®)

Research suggests mirtazapine may help people reduce or stop methamphetamine use by:

Improving sleep

Reducing cravings

Supporting weight gain if malnutrition is present

Decreasing risky behaviors[3]

Mirtazapine also helps with anxiety and depression.

3. Naltrexone (Oral or Extended-Release Injection)

While known for alcohol and opioid addiction, naltrexone may help reduce stimulant cravings—especially when combined with bupropion.[4]

Evidence supports a combination therapy of bupropion + naltrexone for methamphetamine addiction, sometimes referred to as MAT for stimulants.

4. Modafinil

Modafinil is a wakefulness-promoting agent used for sleep disorders. Small studies suggest modafinil may:

Reduce cocaine use episodes

Improve attention and cognitive functioning

Reduce cravings for some individuals[5]

It is used selectively depending on patient history and overall health.

5. Antipsychotic or Mood-Stabilizing Medications

In cases where stimulant use has triggered:

Severe anxiety

Paranoia

Hallucinations

Agitation

Bipolar-like symptoms

Short-term or long-term medications may be appropriate.

ACE Medical carefully balances benefits and risks with each patient.